She and Malcolm possibly have children, as Malcolm's cup spells "DAD".
The first night after Malcolm's first session with Kovacs, Gloria told him not to lose himself in that case as it would ruin his cheerful disposition. Mal replied that their happy and content life could not change with his job and they went to bed.
The next evening Malcolm was again buried in his work and painkillers, and Gloria complained that she didn't get the attention she deserved from him. Malcolm complained that she brings up love whenever he needs to work, and she replied that he brings up work whenever she needs love.
The next evening, Gloria was annoyed that Malcolm had forgotten about the guests. The guests start to tease Long about Kovacs. Unamused, Long tells them in detail about the murder of Blair Roche ruining the evening. Gloria leaves the table and the guests find a pretense to leave as well. Gloria went to the bedroom and left when Malcolm followed her. Then she showed up with a coat and left him alone staring at a Rorscach inkblot.
Later Long and his wife have separated and are attempting to make amends. On November 2, she waited for him near Bernard's stand to meet him on his way from work, not feeling ready to meet him back at the apartment yet. She said she missed Malcolm but could not live with someone who works with criminals and manics and lets their misery affect his personal life. She asked him to ask for a transfer to different work.
Moments later, they are both killed when Adrian Veidt's alien monster is teleported to New York, causing a shockwave that kills half the city.